Endocrine Abstracts

Estradiol (E2) may directly interact with growth factors stimulating cell proliferation and differentiation. Previously, we have demonstrated that E2 through membrane estrogen receptor α (mERα) modulates the lactotroph cell population which exhibit noticeable changes in the pituitary gland. The aim of this study was to analyze the mERα contribution on lactotroph cell proliferation in response to E2 and FGF-2 interaction evaluatin...

Background: Oestrogen can increase bone mineral density (BMD) by decreasing bone turnover, which is mainly seen in trabecular bone. Testosterone can increase bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transsexuals can therefore affect the BMD. For example, in male-to-female individuals (MtFs) a lower BMD before start of CSHT has been described in comparison to healthy control men.Objectives: To investigate the ...

Introduction: Although vitamin D is well known for its function in calcium homeostasis and bone mineralisation, several studies have shown an effect on physical function and muscle strength. Also, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in COPD-patients, supplementation might have a beneficial effect in these patients.Objective: To assess the effect of vitam...

BackgroundCushing’s syndrome due to ectopic ACTH secretion only accounts for 10% of all cases of Cushing’s syndrome and is most often associated with pulmonary neuro-endocrine tumors. Treatment of ectopic ACTH syndrome is predominantly surgical with resection of the tumor. Following resolution of hypercortisolism, previously subclinical Pneumocystis jiroveci infection can become overt due to restored immune response.Clini...